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Rivaroxaban dose

Mefloquine is an inhibitor of P-gp, and rivaroxaban is a substrate of P-gp.Fish Oil, Omega-3 Fatty Acids (Dietary Supplements): Drug interactions with fish oil, omega-3 fatty acids (Dietary Supplements) or fish oil, omega-3 fatty acids (FDA-approved) are unclear at this time.Bismuth Subsalicylate: Salicylates such as aspirin are known to increase bleeding, and bleeding risk may be increased when these drugs are used concomitantly with rivaroxaban.Concurrent use of a single dose of rivaroxaban and ritonavir, a combined P-gp and strong CYP3A4 inhibitor, led to an increase in the steady-state rivaroxaban AUC by 150% and to an increase in Cmax by 60%.Coadministration with vandetanib increased the Cmax and AUC of digoxin, another P-gp substrate, by 29% and 23%, respectively.

Rivaroxaban is contraindicated for use by patients with active major bleeding in the acute phase.Mitotane: Use caution if mitotane and rivaroxaban are used concomitantly, and monitor for decreased efficacy of rivaroxaban and a possible change in dosage requirements.The risk of bleeding should be weighed against the risk of thrombotic events in deciding whether to initiate rivaroxaban therapy in patients at increased risk of bleeding.Defibrotide: Coadministration of defibrotide with antithrombotic agents (anticoagulants and platelet inhibitors) and fibrinolytics (thrombolytic agents) is contraindicated.

Approximately 30% of patients in the second study had the event.Agents that may effect hemostasis, such as sulfinpyrazone, can increase the likelihood of hemorrhage if administered during or immediately before therapy with thrombolytic agents.Lomustine, CCNU: Due to the bone marrow suppressive and thrombocytopenic effects of lomustine, an additive risk of bleeding may be seen in patients receiving concomitant anticoagulants.Receipt of injectable collagenase may cause an ecchymosis or bleeding at the injection site.Ketorolac: An additive risk of bleeding may be seen in patients receiving anticoagulants in combination with other agents known to increase the risk of bleeding such as nonsteroidal antiinflammatory drugs (NSAIDs).If these herbal products are taken concurrently with warfarin, monitor INR and adjust warfarin dosage to attain clinical and anticoagulant endpoints.

No adequate or well-controlled studies of rivaroxaban in pregnant women exist, and dosing for pregnant women has not been established.Modafinil is an inducer of CYP3A4, and rivaroxaban is a substrate of CYP3A4.Ulipristal is a mild inhibitor of P-gp, and rivaroxaban is a substrate of P-gp.Tolvaptan: Coadministration of rivaroxaban and tolvaptan may result in increases in rivaroxaban exposure and may increase bleeding risk.

Reversing the New Anticoagulants - UCSF Medical

Drug interactions with fish oil, omega-3 fatty acids (Dietary Supplements) or fish oil, omega-3 fatty acids (FDA-approved) are unclear at this time.BackgroundA fixed-dose regimen of rivaroxaban, an oral factor Xa inhibitor, has been shown to be as effective as standard anticoagulant therapy for the treatment of.Ethinyl estradiol is a mild inhibitor of CYP3A4, in vitro, and rivaroxaban is a substrate of CYP3A4.Concurrent use of rivaroxaban and ketoconazole, a combined P-glycoprotein and strong CYP3A4 inhibitor, led to an increase in the steady-state rivaroxaban AUC by 160% and Cmax by 70%.Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis.

Geriatric In clinical studies, geriatric patients exhibited higher rivaroxaban plasma concentrations than younger patients (see Pharmacokinetics).Chloramphenicol is an inhibitor of CYP3A4, and rivaroxaban is a substrate of CYP3A4.Ibuprofen lysine: Because ibuprofen can cause GI bleeding, inhibit platelet aggregation, and prolong bleeding time, additive pharmacodynamic effects may be seen in patients receiving anticoagulants.

Orlistat: Patients on chronic stable doses of anticoagulants like rivaroxaban should be monitored closely for changes in coagulation parameters when orlistat is prescribed.Pioglitazone is a mild inducer of CYP3A4, and rivaroxaban is a substrate of CYP3A4.Propafenone: Coadministration of rivaroxaban and propafenone may result in increases in rivaroxaban exposure and may increase bleeding risk.Delay rivaroxaban administration for 24 hours if traumatic puncture occurs.

If a patient taking rivaroxaban also consumes alcohol, monitor the patient for signs of lack of efficacy of rivaroxaban.Additionally, nandrolone decanoate may generate a pharmacodynamic interaction with warfarin by independently affecting the activity of circulating coagulation proteins.Diflunisal: An additive risk of bleeding may be seen in patients receiving anticoagulants in combination with other agents known to increase the risk of bleeding such as nonsteroidal antiinflammatory drugs (NSAIDs).If these drugs are administered concurrently, monitor the patient for signs of lack of efficacy of rivaroxaban.The concomitant use of other drugs that affect hemostasis increases the risk of bleeding.A case of spontaneous spinal epidural hematoma, attributed to dysfunctional platelets from excessive garlic use in a patient not receiving concomitant anticoagulation, has been reported.Bosentan is an inducer of CYP3A4, and rivaroxaban is a substrate of CYP3A4.

Indomethacin: An additive risk of bleeding may be seen in patients receiving anticoagulants in combination with other agents known to increase the risk of bleeding such as nonsteroidal antiinflammatory drugs (NSAIDs).Nefazodone is a potent inhibitor of CYP3A4, and rivaroxaban is a substrate of CYP3A4.

Bexarotene: Coadministration of rivaroxaban and bexarotene may result in decreased rivaroxaban exposure and may decrease the efficacy of rivaroxaban.Patients receiving warfarin that initiate concomitant cod liver oil therapy should have their INR monitored more closely and the dose of warfarin adjusted accordingly.Vorapaxar: Avoid concomitant use of vorapaxar and warfarin or other anticoagulants.Atazanavir: Coadministration of rivaroxaban and atazanavir may result in increases in rivaroxaban exposure and may increase bleeding risk.Tell your healthcare professional if you have had or will have surgery to place a prosthetic heart valve.These increases were smaller than the increases seen with other CYP3A4 and P-gp inhibitors such as ketoconazole and ritonavir, which may be due to the relative difference in P-gp inhibition.Similar increases in pharmacodynamic effects such as factor Xa inhibition and PT prolongation were also observed.Quinidine is an inhibitor of P-glycoprotein (P-gp), and rivaroxaban is a substrate of P-gp.

Rivaroxaban, sold under the brand name Xarelto, among others, is an anticoagulant medication (blood thinner), which is taken by mouth.

Apixaban : MedlinePlus Drug Information

Eslicarbazepine is an inducer of CYP3A4, and rivaroxaban is a substrate of CYP3A4.Miltefosine: Caution is advised when administering miltefosine with anticoagulants, as use of these drugs together may increase risk for bleeding.Mirabegron is a mild inhibitor of CYP3A4, and rivaroxaban is a substrate of CYP3A4.Diclofenac: An additive risk of bleeding may be seen in patients receiving anticoagulants in combination with other agents known to increase the risk of bleeding such as nonsteroidal antiinflammatory drugs (NSAIDs).